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C-R-Newsletter #60:  December 28, 2007 

Our Fifth Anniversary

CRN Scenarios Published

Roadmap Now Available

IEEE Urges MM Funding

The Age of Nanotechnology

Creating Nanotech Communities

Ranking the Risks

Feature Essay: Restating CRN’s Purpose

 

Editor’s Note: Even by our usual busy standards, this has been a remarkably active month -- and year! -- for CRN. To keep up with all the latest happenings on a daily basis, be sure to check our Responsible Nanotechnology weblog.

 

==========
 
Our Fifth Anniversary


It has been five years now since Mike Treder and Chris Phoenix founded the Center for Responsible Nanotechnology in December 2002. In next month’s newsletter, we’ll publish an overview of our accomplishments, our disappointments, and our plans for the future. We would have offered that assessment this month, except we’ve been too busy with everything else that’s going on!

Below you’ll read about this month’s publication of eight detailed nanotechnology scenarios that CRN developed, the release of an important molecular manufacturing roadmap, new books that contain contributions from CRN, several new articles we have posted on the Web, and more. It’s an exciting time to be involved with emerging technologies, and a time when we -- all of us -- are faced with many difficult decisions about managing powerful new capabilities. We appreciate your continued interest, and your support for our efforts.

 
CRN Scenarios Published


On December 11, we released our long-awaited series of nanotechnology scenarios depicting various versions of a near-future world into which transformative manufacturing concepts may emerge. Across eight separate storylines, an international team of policy, technology, and economic specialists organized by CRN imagined in detail a range of plausible, challenging events -- from pandemics to climate crises to international conflicts -- to see how they might affect the development of advanced nanotechnology over the next 15 years.

All eight scenarios, plus an introduction putting them into context, were posted online at Nanowerk.com, as well on CRN’s main website. The scenarios also will be published in the peer-reviewed print journal, Nanotechnology Perceptions, beginning early next year.

In pursuing this ambitious project, we pulled together more than 50 people from six continents, with a range of backgrounds and points of view, as collaborators. Over the course of several months, a unique series of “virtual workshops” -- using a combination of teleconferencing, Internet chat, and online shared documents -- produced eight intriguing scenarios. We hope you’ll find them stimulating and encourage you to offer feedback by joining the conversation at our new CRN-Talk group discussion site.

 
Roadmap Now Available

After two and a half years, and numerous meetings pulling together dozens of researchers, the “Technology Roadmap for Productive Nanosystems” has finally been made available to the public. We offer congratulations to the steering committee, to the sponsors, and especially to the many workshop and working group participants who tirelessly devoted their time and talents to this important undertaking.

Combined with the remarkable progress of the British IDEAS Factory, and the U.S. government report calling for increased funding of research toward bottom-up molecular manufacturing, it's clear that things are moving rapidly forward. CRN's oft-criticized timeline for development of desktop nanofactories seems less extreme with each passing year. (For more on that, see our Feature Essay below.)

 
IEEE Urges MM Funding

It's worth paying attention when a large and respected organization such as the IEEE -- the world's largest professional technology association -- publicly takes a stand calling for funding of research related to molecular manufacturing (MM), also known as molecular nanotechnology.

A recent article on the IEEE’s Tech Talk blog states:

Proposed funding for further research into the potential of molecular nanotechnology is overdue and hopefully will lead to some productive research in this field. . . Hopefully, the combination of announced funding and a research agenda will remove much of the speculation and acrimony that seems to have surrounded molecular nanotechnology and just bring it to where it should have been all along: a field of scientific endeavor.

READ MORE...

 
The Age of Nanotechnology

Another new book on nanotechnology has been published that includes a chapter we contributed. The book is The Age of Nanotechnology, edited by Nirmala Rao Khadpekar. It was published in India, but contains items written by both Indian researchers and by others from around the world. Our chapter is titled "Bridges to Safety, and Bridges to Progress" -- an updated version of this paper, which you can download from our website.

Other recent books that contain contributions from CRN include Worldchanging: A Users Guide for the 21st Century, edited by Alex Steffen, and Nanoethics, edited by Fritz Allhoff, Patrick Lin, James Moor, and John Weckert.

 
Creating Nanotech Communities

CRN has posted another column to the popular Nanotechnology Now web portal, this time authored by our new Director of Research Communities, Jessica Margolin. Her article is titled "Creating Productive Nanotech Communities." Here is the abstract:

Moving forward into a rapidly changing world and making good decisions about safe development and responsible use of advanced nanotechnology will require the creation of healthy, diverse, productive communities of nanotech researchers, students, policy analysts, and interested observers.

We hope you'll read all our columns, offer feedback, and tell others about them too.

 
Ranking the Risks

On the LinkedIn network, D.K. Matai, an engineer, entrepreneur and philanthropist, recently posted a list of 26 areas of serious global risk, and asked people to prioritize them. Here is part of the answer offered by CRN Executive Director Mike Treder…

I've divided the listed risks into four levels of declining concern. On the top level are:

1. Nanotechnology
2. Climate Chaos
3. Environmental Degradation
4. Financial Systemic Risk

Today's nanoscale technologies pose little risk beyond familiar concerns of chemical toxicity and life-cycle assessment. However, as the field progresses toward general-purpose atomically-precise exponential manufacturing, it could present perilous issues ranging from an unstable arms race to severe economic disruption and more. There are as many potential benefits as there are possible dangers, of course, so we shouldn't consider halting or slowing nanotech R&D. What we must do is speed up investigation of the technology's powerful implications and seriously explore various options for international regulation.

Climate chaos already is causing environmental degradation and this will only get worse, possibly much worse and much faster than we are prepared for. Together these two issues easily could lead to financial systemic failures, and that process might be further accelerated by ill-advised attempts to deal with climate change using geoengineering techniques made possible by advanced nanotechnology, with unforeseen consequences causing the whole assemblage to spiral out of control.

READ MORE

 
Feature Essay: Restating CRN’s Purpose
By Jamais Cascio, Director of Impacts Analysis

How soon could molecular manufacturing (MM) arrive? It's an important question, and one that the Center for Responsible Nanotechnology takes seriously. In our recently released series of scenarios for the emergence of molecular manufacturing, we talk about MM appearing by late in the next decade; on the CRN main website, we describe MM as being plausible by as early as 2015. If you follow the broader conversation online and in the technical media about molecular manufacturing, however, you might argue that such timelines are quite aggressive, and not at all the consensus.

You'd be right.

CRN doesn't talk about the possible emergence of molecular manufacturing by 2015-2020 because we think that this timeline is necessarily the most realistic forecast. Instead, we use that timeline because the purpose of the Center for Responsible Nanotechnology is not prediction, but preparation.

While arguably not the most likely outcome, the emergence of molecular manufacturing by 2015 is entirely plausible. A variety of public projects underway today could, with the right results to current production dilemmas, conceivably bring about the first working nanofactory within a decade. Covert projects could do so as well, or even sooner, especially if they've been underway for some time.

CRN's leaders do not focus on how soon molecular manufacturing could emerge simply out of an affection for nifty technology, or as an aid to making investment decisions, or to be technology pundits. The CRN timeline has always been in the service of the larger goal of making useful preparations for (and devising effective responses to) the onset of molecular manufacturing, so as to avoid the worst possible outcomes such technology could unleash. We believe that the risks of undesirable results increase if molecular manufacturing emerges as a surprise, with leading nations (or companies, or NGOs) tempted to embrace their first-mover advantage economically, politically, or militarily.

Recognizing that this event could plausibly happen in the next decade -- even if the mainstream conclusion is that it's unlikely before 2025 or 2030 -- elicits what we consider to be an appropriate sense of urgency regarding the need to be prepared. Facing a world of molecular manufacturing without adequate forethought is a far, far worse outcome than developing plans and policies for a slow-to-arrive event.

There's a larger issue at work here, too, particularly in regards to the scenario project. The further out we push the discussion of the likely arrival of molecular manufacturing, the more difficult it becomes to make any kind of useful observations about the political, environmental, economic, social and especially technological context in which MM could occur. It's much more likely that the world of 2020 will have conditions familiar to those of us in 2007 or 2008 than will the world of 2030 or 2040.

Barring what Nassim Nicholas Taleb calls "Black Swans" (radical, transformative surprise developments that are extremely difficult to predict), we can have a reasonable image of the kinds of drivers the people of a decade hence might face. The same simply cannot be said for a world of 20 or 30 years down the road -- there are too many variables and possible surprises. Devising scenarios that operate in the more conservative timeframe would actually reduce their value as planning and preparation tools.

Again, this comes down to wanting to prepare for an outcome known to be almost certain in the long term, and impossible to rule out in the near term.

CRN's Director of Research Communities Jessica Margolin noted in conversation that this is a familiar concept for those of us who live in earthquake country. We know, in the San Francisco region, that the Hayward Fault is near-certain to unleash a major (7+) earthquake sometime this century. Even though the mainstream geophysicists' view is that such a quake may not be likely to hit for another couple of decades, it could happen tomorrow. Because of this, there are public programs to educate people on what to have on hand, and wise residents of the region have stocked up accordingly.

While Bay Area residents go about our lives assuming that the emergency bottled water and the batteries we have stored will expire unused, we know that if that assumption is wrong we'll be extremely relieved to have planned ahead.

The same is true for the work of the Center for Responsible Nanotechnology. It may well be that molecular manufacturing remains 20 or 30 years off and that the preparations we make now will eventually "expire." But if it happens sooner -- if it happens "tomorrow," figuratively speaking -- we'll be very glad we started preparing early.

 

C-R-Newsletter #59:  November 30, 2007 

Military Nanotechnology Book Review
Nano Risk Perception
Modular Models of Molecular Manufacturing
Shifting International Orders
Acid, Oceans, and Oil
Context is Everything
Feature Essay: Imagining the Future
 

Every month is full of activity for CRN. To follow the latest happenings on a daily basis, be sure to check our Responsible Nanotechnology weblog.

 

==========

 

Military Nanotechnology Book Review

The current issue of the Bulletin of the Atomic Scientists includes a review by Mike Treder, CRN Executive Director, of Jürgen Altmann's important new book, Military Nanotechnology: Potential Applications and Preventive Arms Control. Here is how the article begins:

Deeply researched and carefully worded, Military Nanotechnology is an overview of an emerging technology that could trigger a new arms race and gravely threaten international security and stability. Jürgen Altmann's academic style allows the reader to assess nanotechnology's perilous military implications in plain, dispassionate terms. What we face might sound like science fiction, but, in this book, we have the facts laid bare, and they are hair-raising enough without embellishment.

You can download the full review as a PDF, or look for November/December issue of the magazine at your local bookstore or library.

 
Nano Risk Perception

At his excellent Nanowerk site, Michael Berger writes:

The benefits of new technologies, whether they are new medical treatments, an innovative approach to farming or new ways of generating energy, almost always come with some new risks as well. In the emerging stages of a new technology, experts and the public generally differ in their perceptions of risk... It is not surprising that a new study found that, in general, nanoscientists are more optimistic than the public about the potential benefits of nanotechnology. What is surprising though, is that, for some issues related to the environmental and long-term health impacts of nanotechnology, nanoscientists seem to be significantly more concerned than the public.

We think there is something else revealed by the study Berger cites, which is that scientists and the public are thinking about two different kinds of nanotechnology. Health-related risks and pollution issues are both more typically associated with current and near-future nanoscale technologies, while concerns about privacy erosion, economic disruption, and a new arms race are more often connected with longer-term advanced nanotechnology, i.e. molecular manufacturing. So, the differing responses are not really a surprise at all, if it's understood that each group is considering risks related to technology levels that are vastly different in terms of power and potential.

 
Modular Models of Molecular Manufacturing

In a recent article on CRN’s Responsible Nanotechnology blog, Nato Welch writes about the new “BUG” modular hardware platform and discovers some insights for the future of molecular manufacturing. He compares the modular hardware approach with Tom Craver’s proposal for “nanoblock” use inside nanofactories:

Each nanoblock could be anything -- motors, computers, sensors, memory, etc. The major differences are that nanoblocks would, of course, be much smaller, would be built to atomically-precise specifications, and would have to be assembled by a fabrication device designed for the nanoblock scale, rather than being hand-assembled. The striking similarities between Craver's nanoblocks model and the BUG platform suggests to me that we don't even need to presuppose atomically-precise manufacturing in order to design and deploy the kind of infrastructure Craver suggests... When it arrives, molecular manufacturing could be designed to just plug in to existing fabrication standards already developed for larger-scale systems in the meantime.

 
Shifting International Orders

In the last 100 years, our world has experienced several huge shifts of social, economic, political, and military power. These transitions took place at the ends of World War I, World War II, and the Cold War. Before, between, and after each of those shifts, international order was relatively stable. But within the lifetimes of many people living today, three titanic rearrangements of global power have taken place.

 

Will it happen again? Almost certainly. The big question is when, and how?

In an entry on CRN’s blog, we distinguish four different international orders that have prevailed during the previous 100 years: The Age of Modern Empires (before ~1920), The Rise and Fall of Fascism (~1920 to ~1950), Cold Wars (~1950 to ~1990), and Unipolar Power (~1990 to the present).

If you accept the argument that we're living today in the fourth different period of the last 100 years, it should be obvious that this is not a permanent state. So, what comes next? How can we anticipate it? How might we shape it? And how will the development of powerful new technologies, such as molecular manufacturing, fit into that big picture?

 
Acid, Oceans, and Oil

Over at the WorldChanging site, Emily Gertz reminds us:

Some of the most profoundly disturbing climate crisis news this year has been the growing evidence that the planet's natural systems for absorbing greenhouse gas out of the atmosphere, particularly the oceans, are beginning to fail. There's simply more carbon dioxide in the atmosphere than these powerful sinks can uptake.

While in a related article on the Wired blog network, we read about the end of oil:

If there are any lingering doubts as to whether the age of oil is nearing its end, the International Energy Agency has put them to rest and made it clear that only a massive and immediate investment in sustainable energy will prevent a global crisis.

So, we're running out of cheap oil at the same time that global energy demand is skyrocketing. And as we're pouring more greenhouse gases into the air, the atmosphere and the oceans are becoming less able to recycle those gases.

These are two separate but related crises:

1. We need much more energy, but it's becoming less available and more expensive.
2. Damage to the ecosphere from energy use is rapidly becoming more severe.

Is there a simple solution to both of these complex problems? Almost certainly not. Some will suggest heavy investment in nuclear energy; some will say conversion to solar, wind, or geothermal energy is the answer; some few will recommend drastically scaling back society's energy demands; still others will say that we must embark on radical "re-terraforming" of the Earth.

Finally, there is the whole question of whether we should just admit that climate change can't be stopped, and begin figuring out how to live with it. We may not be that far gone yet, but the signs aren't looking good.

 
Context is Everything

Sometimes when we write about climate change (see above), or geopolitics, or privacy erosion, we’re criticized for straying too far from CRN’s primary topic: safe development and responsible use of molecular manufacturing.

The explanation for this has to do with how we are, over time, coming to see that the issues CRN is nominally concerned with are inextricably linked with a wide range of other topics.

Molecular manufacturing will not be developed in a vacuum, nor will it emerge unhindered into a welcoming world. How, when, or even whether desktop nanofactories are finally produced will depend largely on external factors that have little or nothing to do with nanotech. This is a big drive behind our efforts to create a series of professional-quality scenarios about the near-future development of molecular manufacturing within the context of projected trends in science, technology, and global politics.

The task of designing effective policy toward safe development and responsible use of advanced nanotechnology is both highly complex and vitally important. A broad base of knowledge is required for that, including as good an understanding as we can get of the rapidly changing social, economic, and political systems that atomically-precise exponential manufacturing eventually will encounter. Those new conditions must be taken into account, because the world of circa 2020 is expected to be vastly different from 2007 -- and in developing responsible global solutions, context is everything.

 
Feature Essay: Imagining the Future
By Jamais Cascio, CRN Director of Impacts Analysis

I'm one of the lucky individuals who makes a living by thinking about what we may be facing in the years ahead. Those of us who follow this professional path have a variety of tools and methods at our disposal, from subjective brainstorming to models and simulations. I tend to follow a middle path, one that tries to give some structure to imagined futures; in much of the work that I do, I rely on scenarios.

Recently, the Center for Responsible Nanotechnology undertook a project to develop a variety of scenarios regarding the different ways in which molecular manufacturing might develop. One of the explicit goals of that project was to come up with a broad cross-section of different types of deployment -- and in that task, I think we succeeded.

I'd like to offer up a different take on scenarios for this month's newsletter essay, however. With the last scenario project, we used "drivers" -- the various key factors shaping how major outcomes transpired -- consciously intended to reflect different issues around the development of molecular manufacturing. It's also possible, however, to use a set of drivers with broader applicability, teasing out specific scenarios from the general firmament. Such drivers usually describe very high-level cultural, political and/or economic factors, allowing a consistent set of heuristics to be applied to a variety of topics.

Recently, I developed a set of scenarios for a project called "Green Tomorrows." While the scenario stories themselves concerned different responses to the growing climate crisis, the drivers I used operated at a more general level -- and could readily be applied to thinking about different potential futures for molecular manufacturing. The two drivers, each with two extremes, combine to give four different images of the kinds of choices we'll face in the coming decade or two.

The drivers I chose reflect my personal view that both how we live and how we develop our tools and systems are ultimately political decisions. The first, "Who Makes the Rules?", covers a spectrum from Centralized to Distributed. Is the locus of authority and decision-making limited to small numbers of powerful leaders, or found more broadly in the choices made by everyday citizens, working both collaboratively and individually? The second, "How Do We Use Technology?", runs from Precautionary to Proactionary. Do the choices we make with both current and emerging technologies tend to adopt a "look before you leap" or a "he who hesitates is lost" approach?

So, how do these combine?

 

 
The first scenario, living in the combination of Centralized rule-making and Precautionary technology use, is "Care Bears." The name refers to online games in which players are prevented by the game rules from attacking each other. For players who want no controls, the rules are overly-restrictive and remove the element of surprise and innovation; for players who just want an enjoyable experience, the rules are a welcome relief.

In this scenario, then, top-down rule-making with an emphasis on prevention of harm comes to slow overall rates of molecular manufacturing progress. The result is a world where nanotechnology-derived solutions are harder to come by, but one where nanotechnology-derived risks are less likely, as well. This is something of a baseline scenario for people who believe that regulation, licensing, and controls on research and development are ultimately good solutions for avoiding disastrous outcomes. The stability of the scenario, however, depends upon both how well the top-down controls work, and whether emerging capabilities of molecular manufacturing tempt some people or states to grab greater power. If this scenario breaks, it could easily push into the lower/right world.

The second scenario, combining Centralized rule-making and Proactionary technology use, is "There Once Was A Planet Called Earth..." The name sets out the story fairly concisely: competition between centralized powers seeking to adopt the most powerful technologies as quickly as possible -- whether for benign or malignant reasons -- stands a very strong likelihood of leading to a devastating conflict. For me, this is the scenario most likely to lead to a bad outcome.

Mutually-assured global destruction is not the only outcome, but the probable path out of this scenario is a shift towards greater restrictions and controls. This could happen because people see the risks and act accordingly, but is more likely to happen because of an accident or conflict that brings us to the brink of disaster. In such a scenario, increasing restrictions (moving from proactionary to precautionary) are more likely than increasing freedom (moving from centralized to distributed).

The third scenario, combining Distributed rule-making and Proactionary technology use, is "Open Source Heaven/Open Source Apocalypse." The name reflects the two quite divergent possibilities inherent in this scenario: one where the spread of user knowledge and access to molecular manufacturing technologies actually makes the world safer by giving more people the ability to recognize and respond to accidents and threats, and one where the spread of knowledge and access makes it possible for super-empowered angry individuals to unleash destruction without warning, from anywhere.

My own bias is towards the "Open Source Heaven" version, but I recognize the risks that this entails. We wouldn't last long if the knowledge of how to make a device that would blow up the planet with a single button-push became widespread, and some of the arguments around the destructive potential of late-game molecular manufacturing seem to approach that level of threat. Conversely, it's not hard to find evidence that open source knowledge and access tends to offer greater long-term safety and stability than does a closed approach, and that insufficiently-closed projects leaking out to interested and committed malefactors (but not as readily to those who might help to defend against them) offers the risks of opening up without any of the benefits.

Finally, the fourth scenario, combining Distributed rule-making and Precautionary technology use, is "We Are As Gods, So We Might As Well Get Good At It." Stewart Brand used that as an opening line for his Whole Earth Catalogs, reflecting his sense that the emerging potential of new technologies and social models gave us -- as human beings -- access to far greater capabilities than ever before, and that our survival depended upon careful, considered examination of the implications of this fact.

In this world, the widespread knowledge of and access to molecular manufacturing technologies gives us a chance to deal with some of the more pressing big problems we as a planet face -- extreme poverty, hunger, global warming, and the like -- in effect allowing us breathing room to take stock of what kind of future we'd like to create. Those individuals tempted to use these capabilities for personal aggrandizement have to face a knowledgeable and empowered populace, as do those states seeking to take control away from the citizenry. This is, admittedly, the least likely of the four worlds, sadly.

But you don't have to take my word for it. This "four box" structure doesn't offer predictions, but a set of lenses with which to understand possible outcomes and the strategies that might be employed to reach or avoid them. The world that will emerge will undoubtedly have elements of all four scenarios, as different nations and regions are likely to take different paths. The main purpose of this structure is to prompt discussion about what we can do now to push towards the kind of world in which we'd want to live, and to thrive.

 

C-R-Newsletter #58:  October 31, 2007 

Productive Nanosystems Conference
The Nanofactory Ecosystem
Scenario Publication Plans
Keeping Tabs on China
Monstrous Hybrids Alive
Feynman Prizes Awarded
Foresight Vision Weekend
Guest Science Essay: Exploring the Productive Nanosystems Roadmap

 

Every month is full of activity for CRN. To follow the latest happenings on a daily basis, be sure to check our Responsible Nanotechnology weblog.

 

==========

 

Productive Nanosystems Conference

One of the biggest events of the year in advanced nanotechnology was a recent conference titled “Productive Nanosystems: Launching the Technology Roadmap.” The event, organized by the Society of Manufacturing Engineers, the Foresight Nanotech Institute, and Battelle, was reported extensively -- almost minute-by-minute -- by CRN's Chris Phoenix on our blog, and is also the subject of this month’s guest science essay by Damian Allis (see below). Chris. For your convenience we’ve created a listing of the superb coverage that Chris provided, including every presentation at the conference.

 
The Nanofactory Ecosystem

We’re pleased to report that CRN's latest monthly column for the popular Nanotechnology Now web portal was authored by our new Director of Impacts Analysis, Jamais Cascio. His article is titled "The Nanofactory Ecosystem." Here is the abstract:

In addition to understanding the progress of nanotechnology toward building atomically-precise desktop manufacturing systems -- nanofactories -- we also need to consider the infrastructure needed to sustain that new technology paradigm. What sort of "ecosystem" might spring up around nanofactories?

We hope you'll read all our columns, offer feedback, and tell others about them too.

 
Scenario Publication Plans

CRN is excited to have an agreement with Nanotechnology Perceptions, a peer-reviewed academic journal published by Switzerland's Collegium Basilea, to begin releasing our nanotechnology scenario series starting with their November 2007 issue. They will publish two scenarios in that first issue, then follow with two more in their March 2008 issue, and conclude with the remaining four scenarios in July 2008. Each issue also will include at least one commentary article from a "European perspective." Simultaneous with the November 2007 issue of the journal, all eight of our scenarios will be posted online at the Nanowerk.com site, where they also will host a discussion space for readers. We're quite pleased with both of these arrangements; together they will help us to reach a wide audience for this important project.

 
Keeping Tabs on China

At CRN, we spend a lot of time thinking and writing about China, and we believe with good reason. It's common to hear the last 100 years referred to as "The American Century," and many observers now suggest that the next 100 years eventually will be known as "The Chinese Century."

Of course, a lot could happen to change that outcome. For one thing, China faces huge internal and external challenges on its path to global supremacy. For another, the United States is still the preeminent superpower in both economic and military terms and is likely to remain so for some time.

But in looking outward over the next several decades, it's hard to conceive a plausible scenario of world development that does not include China in some capacity. So, as we try to envision how, where, and when molecular manufacturing will emerge and what its implications will be, we must include China in our calculations of context.


READ MORE


 
Monstrous Hybrids Alive

What's the most important book you could read that's not about science or technology to gain a better understanding of CRN's work?

One strong candidate would be Systems of Survival by the late great social scientist Jane Jacobs. Although the book itself is not especially readable (our “Three Systems” paper includes the most important stuff), her ideas are profound.

Another book we've frequently recommended is Jim Garrison's America as Empire: Global Leader or Rogue Power? It offers a compelling review of previous historical empires, their rise and fall, and compares them with the U.S. today. Most relevant to CRN's work is Garrison's prescription for something he calls network democracy.

Now, we may have a third title to add to this short list: The Shock Doctrine: The Rise of Disaster Capitalism by Naomi Klein. I don't have the book yet, but from what I've heard it looks like a must-read, with a lot to say about the unstable global future into which molecular manufacturing may emerge in the next decade or two.

READ MORE

 
Feynman Prizes Awarded

Every year, the Foresight Institute awards prizes to leaders in research, communication and study in the field of nanotechnology. Prizes are conferred on individuals whose work in research, communication and study are moving society toward the ultimate goal of atomically-precise manufacturing. This year's winners are:

Theory Prize - David Leigh, University of Edinburgh, UK
Experimental Prize - Fraser Stoddart, UCLA
Communication Prize - Robert A Freitas Jr., Institute for Molecular Manufacturing
Distinguished Student Prize - Fung-Suong Ou, Rice University

Congratulations to all!

 
Foresight Vision Weekend

Previous editions of the annual fall conference presented by the Foresight Nanotech Institute have been open only to their "senior associates." But this year, they're opening up the event to related groups, including people involved with CRN. It's got a wide-open format this time too (it’s described as an “un-conference”) with a very broad topic list. For more information on the November 3-4 event in Sunnyvale, California, click here.

 
Guest Science Essay: Exploring the Productive Nanosystems Roadmap
Damian Allis, Research Professor of Chemistry at Syracuse University and Senior Scientist for Nanorex, Inc.

What follows is a brief series of notes and observations about the Roadmap Conference, some of the activities leading up to it, and a few points about the state of some of the research that the Roadmap is hoping to address. All views expressed are my own and not necessarily those of other Roadmap participants, collaborators, my affiliated organizations (though I hope to not straddle that fine line between "instigation" and "inflaming" in anything I present below).

Some Opening Praise for Foresight

There are, basically, three formats for scientific conferences. The first is discipline-intensive, where everyone attending needs no introduction and certainly needs no introductory slides (see the division rosters at most any National ACS conference). The only use of showing an example of Watson-Crick base pairing at a DNA nanotechnology conference of this format is to find out who found the most aesthetically-pleasing image on "the Google."

There is the middle ground, where a single conference will have multiple sessions divided into half-day or so tracks, allowing the carbon nanotube chemists to see work in their field, then spend the rest of the conference arguing points and comparing notes in the hotel lobby while the DNA scientists occupy the conference room. The FNANO conference is of a format like this, which is an excellent way to run a conference when scientists dominate the attendee list.

Finally, there is the one-speaker-per-discipline approach, where introductory material consumes roughly 1/3 of each talk and attendees are given a taste of a broad range of research areas. Such conferences are nontrivial to organize for individual academics within a research plan but are quite straightforward for external organizations with suitable budgets to put together.

To my mind, Foresight came close to perfecting this final approach for nanoscience over the course of its annual Conferences on Molecular Nanotechnology. Much like the organizational Roadmap meetings and the Roadmap conference itself, these Foresight conferences served as two-day reviews of the entire field of nanoscience by people directly involved in furthering the cause. In my own case, research ideas and collaborations were formed that continue to this day that I am sure would not have otherwise. The attendee lists were far broader than the research itself, mixing industry (the people turning research into products), government (the people turning ideas into funding opportunities), and media (the people bringing new discoveries to the attention of the public). Enough cannot be said about the use of such broad-based conferences, which are instrumental in endeavors to bring the variety of research areas currently under study into a single focus, such as in the form of a technology Roadmap.


Why A "Productive Nanosystems" Roadmap?

The semiconductor industry has its Roadmap. The hydrogen storage community has its Roadmap. The quantum computing and cryptography communities have their Roadmaps. These are major research and development projects in groundbreaking areas that are not in obvious competition with one another but see the need for all to benefit from all of the developments within a field (in spirit, anyway). How could a single individual or research group plan 20 years into the future (quantum computing) or plan for the absolute limit of a technology (semiconductor)?

The Technology Roadmap for Productive Nanosystems falls into the former category, an effort to as much take a snapshot of current research and very short-term pathways towards nanosystems in general as it is to begin to plot research directions that take advantage of the continued cross-disciplinary efforts now begun in National Labs and large research universities towards increasing complexity in nanoscale study.

On one far end of the spectrum, the "productive nanosystem" in all of its atomically-precise glory as envisioned by many forward-thinking scientists is a distant, famously debated, and occasionally ridiculed idea that far exceeds our current understanding within any area of the physical or natural sciences. Ask the workers on the first Model T assembly line how they expected robotics to affect the livelihoods and the productivity of the assembly lines of their grandchildren's generation, and you can begin to comprehend just how incomprehensible the notion of a fully developed desktop nanofactory or medical nanodevice is even to many people working in nanoscience.

On the other end of the spectrum (and the primary reason, I think, in molecular manufacturing), it seems rather narrow-minded and short-sighted to believe that we will never be able to control the fabrication of matter at the atomic scale. The prediction that scientists will still be unable in 50 years to abstract a carbon atom from a diamond lattice or build a computer processing unit by placing individual atoms within an insulating lattice of other atoms seems absurd. That is, of course, not to say that molecular manufacturing-based approaches to the positional control of individual atoms for fabrication purposes will be the best approach to generating various materials, devices, or complicated nanosystems (yes, I'm in the field and I state that to be a perfectly sound possibility).

To say that we will never have that kind of control, however, is a bold statement that assumes scientific progress will hit some kind of technological wall that, given our current ability to manipulate individual hydrogen atoms (the smallest atoms we have to work with) with positional control on atomic lattices, seems to be sufficiently porous that atomically precise manufacturing, including the mechanical approaches envisioned in molecular manufacturing research, will continue on undaunted. At the maturation point of all possible approaches to atomic manipulation, engineers can make the final decision of how best to use the available technologies. Basically and bluntly, futurists are planning the perfect paragraph in their heads while researchers are still putting the keyboard together. That, of course, has been and will always be the case at every step in human (and other!) development. And I mean that in the most positive sense of the comparison. Some of my best friends are futurists and provide some of the best reasons for putting together that keyboard in the first place.

Perhaps a sea change over the next ten years will involve molecular manufacturing antagonists beginning to agree that "better methods exist for getting A or B" instead of now arguing that "molecular manufacturing towards A and B is a waste of a thesis."

That said, it is important to recognize that the Technology Roadmap for Productive Nanosystems is not a molecular manufacturing Roadmap, rather a Roadmap that serves to guide the development of nanosystems capable of atomic precision in the manufacturing processes of molecules and larger systems. The difference is largely semantic, though, founded in the descriptors of molecular manufacturing as some of us have come to know and love it.

Definitions!

If we take the working definitions from the Roadmap...

Nanosystems are interacting nanoscale structures, components, and devices.

Functional nanosystems are nanosystems that process material, energy, or information.

Atomically precise structures are structures that consist of a specific arrangement of atoms.

Atomically precise technology (APT) is any technology that exploits atomically precise structures of substantial complexity.

Atomically precise functional nanosystems (APFNs) are functional nanosystems that incorporate one or more nanoscale components that have atomically precise structures of substantial complexity.

Atomically precise self-assembly (APSA) is any process in which atomically precise structures align spontaneously and bind to form an atomically precise structure of substantial complexity.

Atomically precise manufacturing (APM) is any manufacturing technology that provides the capability to make atomically precise structures, components, and devices under programmable control.

Atomically precise productive nanosystems (APPNs) are functional nanosystems that make atomically precise structures, components, and devices under programmable control, that is, they are advanced functional nanosystems that perform atomically precise manufacturing.

The last definition is the clincher. It combines atomic precision (which means you know the properties of a system at the atomic level and can, given the position of one atom, know absolutely about the rest of the system) and programmable control (meaning information is translated into matter assembly). Atomic precision does not mean "mostly (7,7) carbon nanotubes of more-or-less 20 nm lengths," "chemical reactions of more than 90% yield," "gold nanoparticles of about 100 nm diameters," or "molecular nanocrystals with about 1000 molecules." That is not atomic precision, only our current level of control over matter. I am of the same opinion as J. Fraser Stoddart, who described the state of chemistry (in his Feynman Experimental Prize lecture) as "an 18 month old" learning the words of chemistry but unable to speak the short sentences of supramolecular assembly and simple functional chemical systems, make paragraphs of complex devices from self-assembling or directed molecules, or the novels that approach the scales of nanofactories, entire cells, or whatever hybrid system first can be pointed to by all scientists as a first true productive nanosystem.

 

Plainly, there is no elegant, highly developed field in the physical or natural sciences. None. Doesn't exist, and anyone arguing otherwise is acknowledging that progress in their field is dead in the water. Even chiseled stone was state-of-the-art at one point.

The closest thing we know of towards the productive nanosystem end is the ribosome, a productive nanosystem that takes information (mRNA) and turns it into matter (peptides) using a limited set of chemical reactions (amide bond formation) and a very limited set of building materials (amino acids) to make a very narrow range of products (proteins) which just happen to, in concert, lead to living organisms. The ribosome serves as another important example for the Roadmap. Atomic precision in materials and products does not mean absolute positional knowledge in an engineering, fab facility manner. Most cellular processes do not require knowledge of the location of any component, only that those components will eventually come into Brownian-driven contact.

Molecular manufacturing proponents often point to the ribosome as "the example" among reasons to believe that engineered matter is possible with atomic precision. The logical progression from ribosome to diamondoid nanofactory, if that progression exists on a well-behaved wavefunction (continuous, finite -- yeesh-- with pleasant first derivatives), is a series of substantial leaps of technological progress that molecular manufacturing opponents believe may/can/will never be made. Fortunately, most of them are not involved in research towards a molecular manufacturing end and so are not providing examples of how it cannot be done, while those of us doing molecular manufacturing research are both showing the potential, and the potential pitfalls, all the while happy to be doing the dirty work for opponents in the interest in pushing the field along.

It is difficult to imagine that any single discipline will contain within its practitioners all of the technology and know-how to provide the waiting world with a productive nanosystem of any kind. The synthetic know-how to break and form chemical bonds, the supramolecular understanding to be able to predict how surfaces may interact as either part of self-assembly processes or as part of mechanical assembly, the systems design to understand how the various parts will come together, the physical and quantum chemistry to explain what's actually happening and recommend improvements as part of the design and modeling process, the characterization equipment to follow both device assembly and manufacturing: each of these aspects relevant to the assembly and operations of productive nanosystems are, in isolation, areas of current research that many researchers individually devote their entire lives to and that are all still very much in development.

However, many branches of science are starting to merge and perhaps the first formal efforts at systems design among the many disciplines are likely to be considered the ACTUAL beginning of experimental nanotechnology. The interdisciplinaritization (yes, made that one up myself) of scientific research is being pushed hard at major research institutions by way of the development of Research Centers, large-scale facilities that intentionally house numerous departments or simply broad ranges of individual research. Like research efforts into atomically precise manufacturing, the pursuit of interdisciplinary research is a combination of bottom-up and top-down approaches, with the bottom-up effort a result of individual researchers collaborating on new projects as ideas and opportunities allow and the top-down efforts a result of research universities funding the building of Research Centers and, as an important addition, state and federal funding agencies providing grant opportunities supporting multi-disciplinary efforts and facilities.

But is that enough? Considering all of the varied research being performed in the world, is it enough that unionized cats are herding themselves into small packs to pursue various ends, or is there some greater benefit to having a document that not only helps to put their research into the context of the larger field of all nanoscience research, but also helps them draw connections to other efforts? Will some cats choose to herd themselves when presented with a good reason?

The Roadmap is not only a document that describes approaches to place us on the way to Productive Nanosystems. It is also a significant summary of current nanoscale research that came out of the three National Lab Working Group meetings. As one might expect, these meetings were very much along the lines of a typical Foresight Conference, in which every half hour saw a research presentation on a completely different subject that, because each provided a foundation for the development of pathways and future directions, were found to have intersections. The same is true of the research and application talks at the official SME release conference. It's almost a law of science. Put two researchers into a room and, eventually, a joint project will emerge.

On to the Conference

In describing my reactions to the conference, I'm going to skip many, many details, inviting you, the reader, to check out the Roadmap proper when it's made available online and, until then, to read through Chris Phoenix's live-blogging.

As for what I will make mention of...

Pathways Panel

A panel consisting of Schafmeister, Randall, Drexler, and Firman (with Von Ehr moderating) from the last section of the first day covered major pathway branches presented in the Roadmap, with all the important points caught by Chris Phoenix's QWERTY mastery.

I'll spare the discussion, as it was covered so well by Chris, but I will point out a few important take-homes:

Firman said, "Negative results are a caustic subject... while fusing proteins, sometimes we get two proteins that change each other's properties. And that's a negative result, and doesn't get published. It shouldn't be lost." Given the survey nature of the types of quantum chemical calculations being performed to model tooltip designs that might be used for the purposes of mechanosynthesis (molecular manufacturing or otherwise), Drexler, Freitas, Merkle, and myself spend considerable time diagnosing failure modes and possibly unusable molecular designs, making what might otherwise be "negative results" important additions to our respective design and analysis protocols. Wired readers will note that Thomas Goetz covered this topic ("Dark Data") and some web efforts to make this type of data available in Issue 15.10.

I loved the panel’s discussion of replication, long a point of great controversy over concerns and feasibility. Drexler mentioned how his original notion of a "replicator" as proposed in Engines of Creation is obsolete for pragmatic/logistical reasons. But the next comment was from Schafmeister, who, in his research talk, had proposed something that performs a form of replication (yes, that's the experimental chemist making the bold statement); it would be driven externally, but nonetheless something someone could imagine eventually automating. Christian also performed a heroic feat in his talk by presenting his own (admittedly, by him) "science fiction" pathway for applying his own lab research to a far more technically demanding end, something far down the road as part of his larger research vision.

Randall, on the use of the Roadmap, said, "The value of the Roadmap will be judged by the number of people who read it and try to use it. Value will increase exponentially if we come back and update it." The nature of nanoscience research is that six months can mean a revolution. I (and a few others at the very first Working Group meeting) had been familiar with structural DNA nanotechnology, mostly from having seen Ned Seeman present something new at every research talk (that is also a feat in the sciences, where a laboratory is producing quick enough to always have results to hand off to the professor in time for the next conference). The Rothemund DNA Origami paper [PDF] was a turning point to many and made a profound statement on the potential of DNA nanotech. I was amazed by it. Drexler's discussions on the possibilities have been and continue to be contagious. William Shih mentioned that his research base changed fundamentally because of DNA Origami, and seeing the complexity of the designs AND the elegance of the experimental studies out of his group at the Roadmap Conference only cemented in my mind just how fast a new idea can be extended into other applications. It would not surprise me if several major advances before the first revision of the Roadmap required major overhauls of large technical sections. At the very least, I hope that scientific progress requires it.

Applications Panel

A panel consisting of Hall, Maniar, Theis, O'Neill (with Pearl moderating) from the last section of the second day covered applications, with short-term and very long-term visions represented on the panel (again, all caught by Chris Phoenix).

For those who don't know him, Josh Hall was the wildcard of the applications panel, both for his far more distant contemplations on technology than otherwise represented at the conference and for his exhaustive historical perspective (he can synthesize quite a bit of tech history and remind us just how little we actually know given the current state of technology and how we perceive it; O'Neill mentioned this as well, see below). Josh is far and away the most enlightening and entertaining after-dinner raconteur I know. As a computer scientist who remembers wheeling around hard drives in his graduate days, Josh knows well the technological revolutions within the semiconductor industry and just how difficult it can be for even industry insiders to gauge the path ahead and its consequences on researchers and consumers.

Papu made an interesting point I'd not thought of before. While research labs can push the absolute limits of nanotechnology in pursuit of new materials or devices, manufacturers can only make the products that their facilities, or their outsourcing partner facilities, can make with the equipment they have available. A research lab antenna might represent a five-year leap in the technology, but it can’t make it into today's mobile phone if the fab facility can't churn it out in its modern 6 Sigma manifestation.

Nanoscience isn't just about materials, but also new equipment for synthesis and characterization, and the equipment for that is expensive in its first few generations. While it’s perhaps inappropriate to refer to "consumer grade" products as the "dumbed down" version of "research grade" technologies, investors and conspiracy theorists alike can take comfort in knowing that there really is "above-level" technology in laboratories just hoping the company lasts long enough to provide a product in the next cycle.

O'Neill said, "To some of my friends, graphite epoxy is just black aluminum." This comment was in regards to how a previous engineering and technician generation sees advances in specific areas relative to their own mindset and not as part of continuing advancements in their fields. It's safe to say that we all love progress, but many fear change. The progress in science parallels that in technology, and the ability to keep up with the state-of-the-art, much less put it into practice as Papu described, is by no means a trivial matter. Just as medical doctors require recertification, scientists must either keep up with technology or simply see their efforts slow relative to every subsequent generation. Part of the benefit of interdisciplinary research is that the expertise in a separate field is provided automatically upon collaboration. Given the time to understand the physics and the cost of equipment nowadays, most researchers are all too happy to pass off major steps in development to someone else.

Closing Thoughts

Non-researchers know the feeling. We've all fumbled with a new technology at one point or another, be it a new cell phone or a new (improved?) operating system, deciding to either "learn only the basics" or throw our hands up in disgust. Imagine having your entire profession changed from the ground up or, even worse, having your profession disappear because of technology. Research happening today in nanoscience will serve a disruptive role in virtually all areas of technology and our economy. Entire industries, too. Can you imagine the first catalytic system that effortlessly turns water into hydrogen and oxygen gas? If filling the tank of your jimmied VW ever means turning on your kitchen spigot, will your neighborhood gas station survive selling peanut M&M's and Snapple at ridiculous prices?

 

C-R-Newsletter #57:  September 29, 2007 

CRN Leadership Expands

A Successful Nano-Bio Conference

Scenario Publication Plans

Nanoethics Questions

CRN Goes to Hoboken

Journey vs. Destination

Live-Blogging Productive Nanosystems

Feature Essay: Levels of Nanotechnology Development

 

Every month is full of activity for CRN. To follow the latest happenings on a daily basis, be sure to check our Responsible Nanotechnology weblog.

 

==========

 

CRN Leadership Expands

 

The Center for Responsible Nanotechnology is adding two new members to its leadership team. Jamais Cascio will become CRN’s Director of Impacts Analysis, and Jessica Margolin will take on the role of Director of Research Communities, effective October 1, 2007. CRN co-founder Chris Phoenix will begin his scheduled sabbatical in October. Co-founder Mike Treder will continue to serve as Executive Director of CRN.

 

“I’ve been looking forward to this opportunity for some time,” said Phoenix. “With growing recognition about the importance of molecular manufacturing, with Jamais and Jessica, two extremely talented people, coming on board, and with Mike’s ongoing leadership, I feel comfortable taking a sabbatical.”

 

Jamais Cascio is a writer, blogger and futurist covering the intersection of emerging technologies and cultural transformation. He speaks about future scenarios around the world and his essays about technology and society have appeared in a variety of print and online publications. He is a fellow at the Institute for Ethics and Emerging Technologies, as well as a research affiliate at the Institute for the Future. He also works on a variety of independent projects including serving as a lead author of the recent Metaverse Roadmap Overview report.

 

“I’ve admired CRN’s work for a long time,” said Cascio, “and in recent months I’ve become more actively involved. Now I’m extremely pleased to be joining the team in a leadership capacity.”

 

In 2003, Cascio co-founded WorldChanging.com, a Web site dedicated to finding and calling attention to models, tools, and ideas for building a ‘bright green’ future. Cascio authored nearly 2,000 articles during his time at WorldChanging, looking at topics such as energy and the environment, global development, open-source technologies, and catalysts for social change. In 2006, he started OpenTheFuture.com as his online home.

 

Jessica Margolin is an entrepreneur who consults in the area of purposeful conversations and messaging systems. Her professional background includes industry roles in financial analysis, business development, organizational design, and marketing strategy and communications; her education includes an MS in Materials Science in the area of nanotechnology, and an MBA.

 

“It's important to ensure all voices are heard during periods of profoundly rapid scientific innovation,” said Margolin. “Many nanoscale technologies are poised to be disruptive, and CRN focuses on what is potentially the most disruptive of all. I look forward to accelerating the development of the community surrounding CRN's work.”

 

Currently a research affiliate at Institute for the Future, Margolin synthesizes her professional experience in the financial and internet industries as well as her philanthropic work to address problems concerning the design of organizations, institutions, and communities.

 

“I’m ecstatic about the opportunity to work closely with both Jamais and Jessica as we move forward in the important cause of ensuring safe development and responsible use of advanced nanotechnology,” said Treder.

 

 

A Successful Nano-Bio Conference

 

From September 10-12, 2007, CRN was proud to welcome attendees and speakers to our first conference -- "Challenges & Opportunities: The Future of Nano & Bio Technologies” -- hosted and co-organized in Tucson, Arizona, by World Care.

 

We filled three days with compelling speakers, panel discussions and novel interactive collaborations, plus highly enjoyable social hours in the evening. Most of the conference presentations have been posted online for free download, and we’ve also offered short reviews and commentaries on our blog.

 

To really get a feel for the content and flow of the event, read the outstanding live blog coverage provided by Michael Anissimov at Accelerating Future and by Simone Syed for the Frontier Channel. Great thanks to all who participated!

  

 

Scenario Publication Plans


CRN is pleased to have an agreement with Nanotechnology Perceptions, a peer-reviewed academic journal published by Switzerland's Collegium Basilea, to begin releasing our nanotechnology scenario series starting with their November 2007 issue. They will publish two scenarios in that first issue, then follow with two more in their March 2008 issue, and conclude with the remaining four scenarios in July 2008. Each issue also will include at least one commentary article from a "European perspective." Simultaneous with the November 2007 issue of the journal, all eight of our scenarios will be posted online at the Nanowerk.com site, where they also will host a discussion space for readers. We're quite pleased with both of these arrangements; together they will help us to reach a wide audience for this important project.

 

 

Nanoethics Questions

 

Just what is nanoethics, and why does it matter? That's a question posed in the Spring 2007 issue of The New Atlantis. Adam Keiper, the journal's editor, wrote a long article titled "Nanoethics as a Discipline?" in which he challenged the validity of the field as a whole and complained specifically about CRN's "many simplistic political and social assumptions."

 

CRN wrote a lengthy rebuttal pointing out the difficulty of stretching towards understanding in areas where prior work is scant, if it exists at all. At this stage, we're not ready to go into finer detail with either our analyses or proposed solutions. Our task for now is to raise awareness of these issues and to stimulate more comprehensive work by other groups, especially those with deeper expertise in specific areas.

 

We also emphatically rejected Keiper’s intimation that because the future is unknowable, it is therefore uninteresting or unworthy of speculative exploration. Indeed, it is because we cannot say for sure how nanotechnology will evolve and how it will affect society that we feel the need to provoke such discussions. CRN will continue to work on forecasting the future of nanotechnology, on gaining the facts, on defining our values, and on shaping politically realistic solutions that give us the best hope for a safe and responsible world of tomorrow.

 

Others also had strong responses to Keiper’s provocative article, including numerous nanoethics professors and best-selling author David Brin, who wrote a guest commentary for CRN.

 

 

CRN Goes to Hoboken

 

A few weeks ago, CRN Executive Director Mike Treder traveled across the Hudson River to Hoboken, New Jersey, where he presented a seminar on the future of nanotechnology to graduate students and faculty at Stevens Institute of Technology, one of the few universities to offer a graduate program in nanotechnology.

 

Mike said he was impressed to learn, during sit-down sessions with professors and post-grad students, about the remarkable work being done at Stevens. It is an institution on the cutting edge of science and technology, and they show a keen interest in understanding more about the social implications of their technological work.

 

 

Journey vs. Destination

 

CRN's latest monthly column for the popular Nanotechnology Now web portal has been posted. The current article is titled "Nanotechnology: Journey vs. Destination" -- here is the abstract:

Nanotechnology has acquired several distinct meanings over the last few decades. Its development has been marked by this confusion, which has led to concerns from one field of nanotechnology, molecular manufacturing, being applied to other fields. As all fields of nanotechnology continue to develop, molecular manufacturing will reach a point where it is able to accelerate the other fields.

We hope you'll read all our columns, offer feedback, and tell others about them too.

 

 

Live-Blogging Productive Nanosystems

 

Productive Nanosystems: Launching the Technology Roadmap” is the title of an exciting conference coming soon to Arlington, Virginia (USA), organized by the Society of Manufacturing Engineers, the Foresight Nanotech Institute, and Battelle. CRN's Chris Phoenix is planning to attend the October 9-10 event and to "live blog" his observations for us.

 

SPECIAL OFFER: All C-R-Newsletter subscribers are eligible to receive the discounted member rate -- a $200 savings! When registering for the conference, enter priority code 07CF308 and member number 270270 to receive the member rate.

 

 

Feature Essay: Levels of Nanotechnology Development

Chris Phoenix, Director of Research, Center for Responsible Nanotechnology

Nanotechnology capabilities have been improving rapidly. More different things can be built, and the products can do more than they used to. As nanotechnology advances, CRN continually is asked: Why do we focus only on molecular manufacturing, when there's important stuff already being done? This essay will put the various levels of nanotechnology in perspective, showing where molecular manufacturing fits on a continuum of development -- quite far advanced in terms of capabilities. Along the way, this will show which kinds of nanotechnology CRN's concerns apply to.

For another perspective on nanotechnology development, it's worth reading the section on "The Progression of Nanotechnology" (pages 3-6) from a joint committee economic study [PDF] for the U.S. House of Representatives. It does not divide nanotech along exactly the same lines, but it is reasonably close, and many of the projections echo mine. That document is also an early source for the NSF's division of nanotechnology into four generations.

The development arc of nanotechnology is comparable in some ways to the history of computers. Ever since the abacus and clay tablets, people have been using mechanical devices to help them keep track of numbers. Likewise, the ancient Chinese reportedly used nanoparticles of carbon in their ink. But an abacus is basically a better way of counting on your fingers; it is not a primitive computer in any meaningful sense. It only remembers numbers, and does not manipulate them. But I am not going to try to identify the first number-manipulator; there are all sorts of ancient distance-measuring carts, timekeeping devices, and astronomical calculators to choose from. Likewise, the early history of nanotechnology will remain shrouded in myth and controversy, at least for the purposes of this essay.

The first computing devices in widespread use were probably mechanical adding machines, 19th century cash registers, and similar intricate contraptions full of gears. These had to be specially designed and built, a different design for each different purpose. Similarly, the first nanotechnology was purpose-built structures and materials. Each different nanoparticle or nanostructure had a particular set of properties, such as strength or moisture resistance, and it would be used for only that purpose. Of course, a material might be used in many different products, as a cash register would be used in many different stores. But the material, like the cash register, was designed for its specialized function.

Because purpose-designed materials are expensive to develop, and because a material is not a product but must be incorporated into existing manufacturing chains, these early types of nanotechnology are not having a huge impact on industry or society. Nanoparticles are, for the most part, new types of industrial chemicals. They may have unexpected or unwanted properties; they may enable better products to be built, and occasionally even enable new products; but they are not going to create a revolution. In Japan, I saw an abacus used at a train station ticket counter in the early 1990's; cash registers and calculators had not yet displaced it.

The second wave of computing devices was an interesting sidetrack from the general course of computing. Instead of handling numbers of the kind we write down and count with, they handled quantities -- fuzzy, non-discrete values, frequently representing physics problems. These analog computers were weird and arcane hybrids of mechanical and electrical components. Only highly trained mathematicians and physicists could design and use the most complex of these computers. They were built this way because they were built by hand out of expensive components, and it was worth making each component as elegant and functional as possible. A few vacuum tubes could be wired up to add, subtract, multiply, divide, or even integrate and differentiate. An assemblage of such things could do some very impressive calculations -- but you had to know exactly what you were doing, to keep track of what the voltage and current levels meant and what effect each piece would have on the whole system.

Today, nanotechnologists are starting to build useful devices that combine a few carefully-designed components into larger functional units. They can be built by chemistry, self-assembly, or scanning probe microscope; none of these ways is easy. Designing the devices is not easy. Understanding the components is somewhat easy, depending on the component, but even when the components appear simple, their interaction is likely not to be simple. But when your technology only lets you have a few components in each design, you have to get the most you can out of each component. It goes without saying that only experts can design and build such devices.

This level of nanotechnology will enable new applications, as well as more powerful and effective versions of some of today's products. In a technical sense, it is more interesting than nanoparticles -- in fact, it is downright impressive. However, it is not a general-purpose technology; it is far too difficult and specialized to be applied easily to more than a tiny fraction of the products created today. As such, though it will produce a few impressive breakthroughs, it will not be revolutionary on a societal scale.

It is worth noting that some observers, including some nanotechnologists, think that this will turn out to be the most powerful kind of nanotechnology. Their reasoning goes something like this: Biology uses this kind of elegant highly-functional component-web. Biology is finely tuned for its application, so it must be doing things the best way possible. And besides, biology is full of elegant designs just waiting for us to steal and re-use them. Therefore, it's impossible to do better than biology, and those who try are being inefficient in the short term (because they're ignoring the existing designs) as well as the long term (because biology has the best solutions). The trouble with this argument is that biology was not designed by engineers for engineers. Even after we know what the components do, we will not easily be able to modify and recombine them. The second trouble with the argument is that biology is constrained to a particular design motif: linear polymers modified by enzymes. There is no evidence that this is the most efficient possible solution, any more than vacuum tubes were the most efficient way to build computer components. A third weakness of the argument is that there may be some things that simply can't be done with the biological toolbox. Back when computers were mainly used for processing quantities representing physical processes, it might have sounded strange to say that some things couldn't be represented by analog values. But it would be more or less impossible to search a billion-byte text database with an analog computer, or even to represent a thousand-digit number accurately.

It may seem strange to take a circuit that could add two high-precision numbers and rework it into a circuit that could add 1+1, so that a computer would require thousands of those circuits rather than dozens. But that is basically what was done by the designers of ENIAC, the famous early digital computer. There were at least two or three good reasons for this. First, the 1+1 circuit was not just high-precision, it was effectively infinite precision (until a vacuum tube burned out) because it could only answer in discrete quantities. You could string together as many of these circuits as you wanted, and add ten- or twenty-digit numbers with infinite precision. Second, the 1+1 circuit could be faster. Third, a computer doing many simple operations was easier to understand and reprogram than a computer doing a few complex operations. ENIAC was not revolutionary, compared with the analog computers of its day; there were many problems that analog computers were better for. But it was worth building. And more importantly, ENIAC could be improved by improving just a few simple functions. When transistors were invented, they quickly replaced vacuum tubes in digital computers, because digital computers required fewer and less finicky circuit designs.

The third level of nanotechnology, which is just barely getting a toehold in the lab today, is massively parallel nano-construction via relatively large computer-controlled machines. For example, arrays of tens of thousands of scanning probes have been built, and these arrays have been used to build tens of thousands of micro-scale pictures, each with tens of thousands of nano-scale dots. That's a billion features, give or take an order of magnitude -- pretty close to the number of transistors on a modern computer chip. That is impressive. However, a billion atoms would make an object about the size of a bacterium; this type of approach will not be used to build large objects. And although I can imagine ways to use it for general-purpose construction, it would take some work to get there. Because it uses large and delicate machines that it cannot itself build, it will be a somewhat expensive family of processes. Nevertheless, as this kind of technology improves, it may start to steal some excitement from the bio-nano approach, especially once it becomes able to do atomically precise fabrication using chemical reactions.

Massively parallel nano-construction will likely be useful for building better computers and less expensive sensors, as well as a lot of things no one has thought of yet. It will not yet be revolutionary, by comparison with what comes later, but it starts to point the way toward revolutionary construction capabilities. In particular, some nano-construction methods, such as Zyvex's Atomically Precise Manufacturing, might eventually be able to build their improved versions of their own tools. Once computer-controlled nano-fabrication can build improved versions of its own tools, it will start to lead to the next level of nanotechnology: exponential manufacturing. But until that point, it appears too primitive and limited to be revolutionary.

ENIAC could store the numbers it was computing on, but the instructions for running the computation were built into the wiring, and it had to be rewired (but not rebuilt) for each different computation. As transistors replaced vacuum tubes, and integrated circuits replaced transistors, it became reasonable for computers to store their own programs in numeric form, so that when a different program was needed, the computer could simply read in a new set of numbers. This made computing a lot more efficient. It also made it possible for computers to help to compile their own programs. Humans could write programs using symbols that were more or less human-friendly, and the computer could convert those symbols into the proper numbers to tell the computer what to do. As computers became more powerful, the ease of programming them increased rapidly, because the symbolic description of their program could become richer, higher-level, and more human-friendly. (Note that, in contrast, a larger analog computer would be more difficult to program.) Within a decade after ENIAC, hobbyists could learn to use a computer, though computers were still far too expensive for hobbyists to own.

The fourth level of nanotechnology is early exponential manufacturing. Exponential manufacturing means that the manufacturing system can build most of its key components. This will radically increase the throughput, will help to drive down the cost, and also implies that the system can build improved versions of itself fairly quickly. Although it's not necessarily the case that exponential manufacturing will use molecular operations and molecular precision (molecular manufacturing), this may turn out to be easier than making exponential systems work at larger scales. Although the most familiar projections of molecular manufacturing involve highly advanced materials such as carbon lattice (diamondoid), the first molecular manufacturing systems likely will use polymers that are weaker than diamondoid but easier to work with. Exponential manufacturing systems with large numbers of fabrication systems will require full automation, which means that each operation will have to be extremely reliable. As previous science essays have discussed, molecular manufacturing appears to provide the required reliability, since covalent bonding can be treated as a digital operation. In the same way that the 1+1 circuit is more precise than the analog adder, adding a small piece onto a molecule can be far more precise and reliable than any currently existing manufacturing operation -- reliable enough to be worth doing millions of times rather than using one imprecise bulk operation to build the same size of structure.

Early exponential manufacturing will provide the ability to build lots of truly new things, as well as computers far in advance of today's. With molecular construction and rapid prototyping, we will probably see breakthrough medical devices. Products may still be quite expensive per gram, especially at first, since early processes are likely to require fairly expensive molecules as feedstocks. They may also require some self-assembly and some big machines to deal with finicky reaction conditions. This implies that for many applications, this technology still will be building components rather than products. However, unlike the cost per gram, the cost per feature will drop extremely rapidly. This implies far less expensive sensors. At some point, as products get larger and conventional manufacturing gets more precise, it will be able to interface with molecular manufactured products directly; this will greatly broaden the applications and ease the design process.

The implications of even early molecular manufacturing are disruptive enough to be interesting to CRN. Massive sensor networks imply several new kinds of weapons, as do advanced medical devices. General-purpose automated manufacturing, even with limitations, implies the first stirrings of a general revolution in manufacturing. Machines working at the nanoscale will not only be used for manufacturing, but in a wide variety of products, and will have far higher performance than larger machines.

In one sense, there is a continuum from the earliest mainframe computers to a modern high-powered gaming console. The basic design is the same: a stored-program digital computer