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Note: The Center for Responsible Nanotechnology is an affiliate of World Care, an international, non-profit, 501(c)(3) organization. The opinions expressed by CRN in our newsletters and elsewhere do not necessarily reflect those of World Care.

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C-R-Newsletter #62:  March 31, 2008

Powerful Nanoscale Computer Created

More Enabling Technologies

Visions of the Future

Empowering Hope

Disruptive Nanotechnology

Religion & Nanotech

New Nano TV Show

Debating CRN's Scope

Archiving Nanotech Interviews

Guest Science Essay: Atomic Force Microscopy

 

Every month is full of activity for CRN. To follow the latest happenings on a daily basis, be sure to check our Responsible Nanotechnology weblog.

 

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Powerful Nanoscale Computer Created

A potentially powerful new form of nanoscale computing has been developed by scientists in Japan. BBC News describes the development as a "tiny chemical 'brain' which could one day act as a remote control for swarms of nano-machines." The innovative device is made of duroquinone, a compound composed of carbon, hydrogen, and oxygen, which suggests that it might become a key component of an early-generation nanofactory. MSNBC has an excellent article online about the new computing technique and also offers an interesting video to illustrate it.

 
More Enabling Technologies

CRN has been tracking numerous examples of enabling technologies that may help pave the way for molecular manufacturing. Over the last several weeks, these are some of the most interesting that we’ve found:
 

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Using DNA nanotechnology to build three-dimensional crystals

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Remote-control DNA 'pistons' could power tiny robots

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'Nanosculptors' carve atom by atom


 
Visions of the Future

A new three-part TV series from the BBC features leading theoretical physicist and futurist Dr Michio Kaku exploring the cutting edge of science. In part three of the series, Kaku says:

“Amazingly, we can now manipulate individual atoms. We can pick them up, move them around, and even play with them. Today we can manipulate individual atoms, but this is just the beginning of a journey -- a journey which will ultimately give us the power to manipulate the very stuff of our universe: matter itself. We are on the brink of a revolution which will give us control -- exquisite control -- of our physical world.”

Part three covers, among other things, bloodstream nanobots, space elevators, invisibility, teleportation, and military nanobots. A good deal of time is also spent presenting the concept of a desktop nanofactory. You can watch all three parts online.

 
Empowering Hope

CRN’s latest monthly column for the popular Nanotechnology Now web portal is by our Director of Impacts Analysis, Jamais Cascio. His article is titled "Super-Empowered Hopeful Individuals." Here is the abstract:

Most discussions of the benefits of molecular manufacturing tend to focus either on broad social advances or individual desires that such a transformative technology may be able to satisfy. These are surely useful ways of thinking about a nanotech-enabled world. But what if this model misses another category, one that may be less noticeable precisely because we pay so much attention to its opposite?

We hope you'll read all our columns, offer feedback, and tell others about them too.

 
Disruptive Nanotechnology

A California newspaper, Palo Alto Weekly, has a cover story on nanotechnology. It's a long article that covers both current work in nanoscale technologies and the more futuristic possibilities of molecular manufacturing. CRN executive director Mike Treder was interviewed for the piece and quoted extensively in it. You can read the whole article online.

 
Religion & Nanotech

In February, the University of Wisconsin-Madison released the results of a study on religion and nanotechnology. A press release about their findings deals with the question: “Is nanotechnology morally acceptable?”

The article generated significant coverage online, including numerous comments at CRN’s blog.

 
New Nano TV Show

"Nanotechnology: The Power of Small" is coming to U.S. public television stations in April 2008. The program, produced by the Fred Friendly Seminars and sponsored by the National Science Foundation, comprises three episodes:
 

  1. PRIVACY - Watching You Watching Me

  2. HEALTH - Forever Young

  3. ENVIRONMENT - Clean, Green, and Unseen


CRN’s Mike Treder was asked by the makers of the program to preview it and give them a reaction. Afterwards, he wrote:

Imagine yourself sitting in an audience at a university symposium and watching a large and diverse panel of experts from science, business, and activist groups debate the merits of advanced nanotechnology. That's exactly the experience you'll have in viewing this program. Unlike many so-called science specials on TV these days, "The Power of Small" takes its subject seriously and treats its audience as intelligent, discriminating adults. Thankfully, there are no flashy graphics, no distracting camera tricks or special effects; just smart, thoughtful people led by a capable moderator discussing provocative issues. Overall, I was quite impressed.

 
Debating CRN's Scope

Although we call ourselves the Center for Responsible Nanotechnology, we've confined our focus to a specific, powerful application of advanced nanotechnology known as molecular manufacturing. However, not everyone believes that CRN should continue concentrating only on molecular manufacturing and its implications. We’ve recently had a good long discussion on our blog about whether, how, and why CRN should consider expanding our scope. Please let us know if you have anything to add!

 
Archiving Nanotech Interviews

Sander Olson is one of the original developers of the NanoApex and NanoMagazine websites. Over the years, Sander has conducted numerous conversations with notable figures working in or commenting on the field of nanotechnology. Since the acquisition of his sites in 2005 by the International Small Technology Network, many of Sander's interviews have not been available on the web.

To correct this, CRN created a page on our main website as an archive of his interviews. In recent weeks, we’ve added Sander’s in-depth talks with Jeff Chinn, Hugo DeGaris, Jack Dunietz, Glenn Fishbine, J. Storrs Hall, Jeffrey Harrow, Gary Mezo, Jagdish Narayan, and James Talton.

 
Guest Science Essay: Atomic Force Microscopy
By Michael Berger, editor-in-chief of Nanowerk

(This article was originally published on March 10, 2008, at Nanowerk.com and is reprinted here by permission.)

Whenever you read an article about nano this or nano that, chances are you come across a large number of confusing three-letter acronyms - AFM, SFM, SEM, TEM, SPM, FIB, CNT and so on. It seems scientists earn extra kudos when they come up with a new three-letter combination. One of the most important acronyms in nanotechnology is AFM - Atomic Force Microscopy. This instrument has become the most widely used tool for imaging, measuring and manipulating matter at the nanoscale and in turn has inspired a variety of other scanning probe techniques.

Originally the AFM was used to image the topography of surfaces, but by modifying the tip it is possible to measure other quantities (for example, electric and magnetic properties, chemical potentials, friction and so on), and also to perform various types of spectroscopy and analysis. Today we take a look at one of the instruments that has it all made possible. So far, over 20,000 AFM-related papers have been published; over 500 patents were issued related to various forms of scanning probe microscopes (SPM); several dozen companies are involved in manufacturing SPM and related instruments, with an annual worldwide turnover of $250–300 million, and approx. 10,000 commercial systems sold (not counting a significant number of home-built systems).

To put the AFM in its context: The reason why nanosciences and nanotechnologies have taken off with such amazing force over the past 20 years is because our ongoing quest for miniaturization has resulted in tools such as the AFM (invented in 1986) or its precursor, the scanning tunneling microscope (STM; invented in 1982. IBM has a website with a gallery of STM images here). Combined with refined processes such as electron beam lithography, this allowed scientists to deliberately manipulate and manufacture nanostructures, something that wasn't possible before.

These engineered nanomaterials, either by way of a top-down approach (a bulk material is reduced in size to nanoscale particles) or a bottom-up approach (larger structures are built or grown atom by atom or molecule by molecule), go beyond just a further step in miniaturization. They have broken a physical barrier beyond, or rather: below, which the standard laws of physics are replaced by what is called "quantum effects". Any material reduced to the nanoscale can suddenly show very different properties than to what it shows on a macro- and larger scale. For instance, opaque substances become transparent (copper); inert materials become catalysts (platinum); stable materials turn combustible (aluminum); solids turn into liquids at room temperature (gold); insulators become conductors (silicon).

A second important aspect of the nanoscale is that the smaller nanoparticles get the larger their relative surface area becomes. The larger the relative surface area, the more reactive a particle becomes with regard to other substances. The fascination with nanotechnology stems from these unique quantum and surface phenomena that matter exhibits at the nanoscale, enabling novel applications and interesting materials.

But without the AFM, all this wouldn't be happening.

The term microscope in the name is actually a misnomer because it implies looking, while in fact the information is gathered by feeling the surface with a mechanical probe. The operation principle of an AFM is based on three key elements:

1) an atomically sharp tip (the "probe"), placed at the end of a flexible cantilever beam, that is brought into physical contact with the surface of a sample. The cantilever beam deflects in proportion to the force of interaction;

2) a piezoelectric transducer to facilitate positioning and scanning the probe in three dimensions over the sample with very precise movements; and

3) a feedback system to detect the interaction of the probe with the sample.

Scanning across the surface, the sharp tip follows the bumps and grooves formed by the atoms on the surface. By monitoring the deflections of the flexible cantilever beam one can generate a topography of the surface.

This principle has been the basis for one of the most important nanoscience tools and allowed the visualization of nanoscale objects where conventional optics cannot resolve them due to the wave nature of light.

A recently published article in the Encyclopedia of Life Sciences, written by Martijn de Jager and John van Noort, both from the University of Leiden in the Netherlands, gives an excellent overview of Atomic Force Microscopy and its applications in life sciences. Below we are summarizing some of the key information from this article.

The AFM can be operated in a number of modes, depending on the application but four modes are most commonly used for AFM imaging: contact mode (or constant height mode), where the deflection of the cantilever is directly used as a measure for the height of the tip and the normal force applied to the sample scales directly with its height. In constant force mode, the normal force the cantilever deflection under scanning reflects repulsive forces acting upon the tip, and at sufficiently small scanning velocities the force feedback can reduce the normal force. Tapping mode (or noncontact mode), where the tip is vibrated (oscillating at its resonance frequency) perpendicular to the specimen plane to avoid gouging the specimen as the tip is scanned laterally and the lateral forces are reduced. In a fourth mode of scanning, the force–distance mode, the tip is brought to the sample at frequencies far below the resonance frequency of the cantilever while at the same time the deflection is recorded. This allows one to measure the local interaction as a function of the tip-sample distance.

As de Jager and van Noort write in their article, large numbers of various biological samples, including cells, cell compartments and biomolecules, have been studied with AFM. "In some of these studies, AFM is used as a plain imaging tool to investigate the topography of immobilized and/or fixed samples, complementing existing methods such as electron microscopy, with the advantage that sample preparation is generally more straightforward. For other experiments, the use of AFM is a prerequisite to look at nonfixed materials and even their dynamics in aqueous environment. Besides its imaging capabilities AFM is becoming increasingly important as a nanomanipulation tool. The single-molecule analysis of interaction forces, elasticity and tertiary protein structure in intact biological materials is uniquely possible using AFM."

Introducing this vast body of research is beyond the scope of any article. Let's just take a look at two examples illustrated in the paper:

Imaging Cells

"AFM imaging of living cells provides a direct measurement of cell morphology with nanometer resolution in three dimensions. Because of its noninvasive nature and the absence of fixation and staining, even dynamic processes like exocytosis, infection by virus particles and budding of enveloped viruses have been successfully visualized in successive scans. Owing to the high elasticity of the cell membrane, the tip can deeply indent the cell without disrupting the membrane. Making use of this effect, even submembraneous structures such as cytoskeletal elements or organelles like transport vesicles can be revealed. However, due to the elasticity of the cell the contact area between the tip and the sample increases with increasing applied force. The elastic modulus of living cells varies between 10 and 100 kPa, which results in a tip sample contact area of 50–100nm in the softest region of the cell. Therefore, the (sub-) nanometer resolution that is routinely achieved on more rigid samples cannot be achieved on membranes of intact cells."

Structure, Function and Interaction of Single DNA and Protein Molecules

"Besides the analysis of cells and cell membranes, AFM-based methods to study purified single molecules like proteins, deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) have developed rapidly in the past decade. Unique details on the mechanism and function of DNA- and RNA metabolizing proteins can directly be obtained by quantification of the number, position, volume and shape of protein molecules on their substrate. Like other single molecule techniques all individual instances of the entire population of structures are revealed, also showing rare but important species. Further insights in the mechanism of a reaction can be obtained from image analysis by measuring parameters such as protein-induced DNA bending, wrapping and looping. Besides topography imaging, force spectroscopy has been successful in unraveling tertiary structure in proteins, RNA and other polymers."

Although it already is an essential tool for structural analysis and manipulation of complex macromolecules and living cells, it is to be expected that AFM-based applications will be further extended in the future. Technical developments will advance the AFM system itself, by improvement of resolution, image rate, sensitivity and functionality. A combination with complementary techniques will fill in some limitations of AFM.

To fully exploit the potential of AFM to study functional biomolecules and their interactions, de Jager and van Noort say that video microscopy would be needed to capture dynamic events. "Currently, the scan rate is limited by the mechanical response of the cantilever and the piezo. Smaller cantilevers will result in higher resonance frequencies, allowing faster scanning rates. By reducing the size of the cantilevers one order of magnitude, the frame rate can be reduced from typically a minute down to video rate, allowing the study of a significantly larger range of biomolecular processes."

The two researchers expect the most important developments for the tip itself. "Image resolution in all modes is dependent on tip geometry. The reduction of tip size, increase of its aspect ratio and its resistance to wear as a result of scanning will have a considerable impact on all AFM applications."

For instance, researchers at Harvard and Stanford universities have developed a specially designed AFM cantilever tip, the torsional harmonic cantilever (THC), which offers orders of magnitude improvements in temporal resolution, spatial resolution, indentation and mechanical loading compared to conventional tools.

With high operating speed, increased force sensitivity and excellent lateral resolution, this tool facilitates practical mapping of nanomechanical properties.

 

 

C-R-Newsletter #61:  January 31, 2008 

U.S. Basic Science in Decline

Is the Future Safe?

Insights from Nanotechnology Scenarios

Wise-Nano Wiki Upgrade

Mind Changing

Enabling Nanotech Update

Feature Essay: CRN at Five Years Old

 

Every month is full of activity for CRN. To follow the latest happenings on a daily basis, be sure to check our Responsible Nanotechnology weblog.

 

==========
 
 

U.S. Basic Science in Decline

January brought gloomy news about the state of basic science research in the United States. We read about big cuts in funding for high-energy physics and fusion programs, important national research laboratories, and biomedical research.

Does it matter to the rest of the world if science funding in the United States is flat or declining? We think it does, partly because the U.S. economy and federal budgets are by far the largest in the world — meaning they have the ability to support more basic science research than anyone else — but also because so much vital policy toward science and technology emanates from the United States.

If the U.S. government is unwilling to provide adequate funding for basic science, that sends a message to business, government, and research institutions worldwide: that science is less important than other priorities (such as making war and making profits), and that the benefits of basic research are not worth supporting, even if it means that future generations — not to mention our own generation — will suffer as a result.

 

Is the Future Safe?

A recurring theme on our Responsible Nanotechnology blog this month was the future of conflict and violence. Are they truly on the decline, as some analysis suggests, and if so, can that happy development be maintained?

Read more about it in our blog entries on The Death of Murder, Soldiers Gone, and Potential for Nano Warfare.  

 

Insights from Nanotechnology Scenarios

Our latest monthly column for the popular Nanotechnology Now web portal has been posted. This month's entry is by CRN’s Director of Impacts Analysis, Jamais Cascio. His article is titled “What Did We Learn?

Here is how it begins:

As enjoyable as it can be to construct future histories and stories of what the coming years might hold, the goal of a scenario planning process is to help people make better decisions by giving them a sense of the implications of different choices. While the individual scenarios trigger their own particular conclusions, several insights arise from looking at the set of scenarios as a whole…

 

Wise-Nano Wiki Upgrade

Many of our readers probably are familiar with the Wise-Nano wiki site started a few years ago by CRN. Recently, we completed a successful upgrade to the site’s MediaWiki software, using the expert assistance of Nato Welch, CRN's Tech Support Specialist.

We invite everyone to take a look at the material collected by the community at Wise-Nano, and consider making your own contributions. That could be done by improving, editing, discussing, or expanding on existing material, or contributing one or more articles of your own that are relevant to the development of molecular manufacturing.

 

Mind Changing

What have you changed your mind about?

That's the annual question for this year at Edge.com. A total of 165 thinkers from around the world gave their answers.

A few of our favorites were Laurence Smith, who discussed the collapse of Arctic sea ice, Roger Schank, who wrote about the possibilities for Artificial Intelligence, Oliver Morton, who changed his mind about human spaceflight, Carolyn Porco, who's thinking about the ways our future on this planet might evolve, Lee Silver, who has new thoughts on the persistence of supernatural beliefs, Kevin Kelly, who now thinks differently about the Wikipedia, William Calvin, who wrote about abrupt climate change, and Martin Rees, who has reconsidered his ideas about very long-term planning.

 

Enabling Nanotech Update

Enabling nanotechnologies are those that may represent significant steps toward the eventual realization of exponential general-purpose molecular manufacturing. These kinds of technologies are not yet molecular manufacturing, in the classic sense, and in fact their developers may not be actively working in that direction. However, progress made by these technologies can bear watching, because they may enable, or make easier, the development of significant portions of molecular manufacturing's full range of needed technical capabilities.

Over the last few weeks, we’ve seen reports on four specific technological developments that we thought were of special interest. You can read about them here:

“DNA Fabricator” and “Darkest Ever Material”

“World’s Best Microscope” and “Perfect Nanowires”

 

Feature Essay: CRN at Five Years Old

By Mike Treder, Executive Director

In our previous newsletter, we promised that this month we would offer an assessment of CRN’s first five years and present an overview of our accomplishments, our disappointments, and our plans for the future.

A useful way to approach this task might be to go back and consider what we believed and what we said when we started CRN and what we have learned since then.

Early in 2003, we published the following foundational statements that summarized CRN's basic positions:

A) Effective use of nanotechnology can benefit everyone.

Advanced nanotechnology promises the ability to build precise machines and components of molecular size. Using mechanically guided chemistry, rapid prototyping, and automated assembly, a nanofactory could combine components into large and complex products. A personal nanofactory should be able to provide cheap, clean, rapid manufacturing; the resulting abundance has the potential to alleviate most shortages, and enable a high standard of living for everyone who has access to it. Rapid, cheap, flexible manufacturing will allow swift development of new inventions, spurring innovation and creating further benefits. We are dedicated to the principle of making these benefits available as widely as possible through effective administration of molecular manufacturing.

B) Unwise use of nanotechnology can be very dangerous.

A technology this powerful could easily be misused. The rapid development cycle and massive manufacturing capability may lead to an unstable arms race between competing powers. Excessive restrictions may lead to an inhumane gap between rich and poor, and may encourage a black market in bootleg, unsafe molecular manufacturing technology. Insufficient restrictions may allow small groups and even individuals to produce undesirable products or terrorist tools. The products of a nanofactory could have unprecedented power and efficiency. Some restrictions, implemented worldwide, will probably be necessary for sufficient control of the use of molecular manufacturing.

C) Nanofactory technology can be used safely.

The manufacturing capability of advanced nanotechnology might be encapsulated in a device of convenient size, with built-in mechanisms for restricting the products it can make. A box the size of a microwave oven would provide ample manufacturing capacity for a household; such a format would be suitable for private ownership, and is easily large enough to contain all necessary functionality for safe use, including elimination of any chemical emissions, and various security technologies. The security features would ensure that the factory would only make approved products; several approval processes could be instituted for the use of various groups and situations. By using nanofactories with built-in restrictions, necessary control could be imposed while allowing widespread use of molecular manufacturing.

D) Preventing nanotechnology is impossible; careful study will be necessary for wise use.

Many nations around the world have already established nanotechnology programs, spending hundreds of millions of dollars per year. Many enabling technologies are developing rapidly. There is no realistic way to relinquish or prevent all development that could lead to robust molecular manufacturing, and there are compelling military and economic reasons for its development—in many different countries. Meanwhile, estimates of the technology's ultimate potential, and the timeline and cost for development, vary widely. Information is power; only through intensive studies can we ensure that the developers and the future administrators of this powerful capability have the tools they need to make the right decisions. A detailed understanding of molecular manufacturing technology is necessary to prepare for its eventual development.

E) Effective use of nanotechnology will require intelligent and prudent policy-making.

Like a computer, a nanotechnology manufacturing system could be incredibly flexible—useful for a wide range of tasks. The administration of a single technology with a multitude of uses, many of them dangerous, poses a unique problem. No single organization can effectively tackle this problem. A single point of control will not be responsive enough to choose the correct set of restrictions for every case, when decisions must be made rapidly and too much restriction may be as bad as too little; however, some worldwide control will probably be necessary. An organization with a single focus, such as military or commercial, cannot make good decisions about unrelated purposes; an organization that tries to accommodate everyone will probably make unwise compromises. Predicting the effects of any choice will require a detailed understanding of the potential of the technology. Well-informed policy must be set, and administrative institutions carefully designed and established, before molecular manufacturing is developed.

F) The situation is urgent; nanofactories may be developed within a decade.

Development of molecular manufacturing technology will rapidly become easier. Computer chips have parts only 120 atoms wide, and getting smaller; molecules bigger than that have already been constructed. Several technologies allow direct creation of complex structures less than 20 atoms wide, and single-atom lithography is being developed. Automated assembly has been used for decades; rapid prototyping is quickly developing from industrial to home use. Molecular manufacturing and assembly will be simpler and easier in many ways than normal manufacturing. Rapid development programs, some of which may be secret, competitive, and unregulated, will be driven by powerful economic and military incentives. To be prepared for the coming development of molecular manufacturing technology, we must start planning for it immediately.

Let’s take those points one at a time and see if they still apply today, in early 2008. 

Effective use of nanotechnology can benefit everyone. What’s suggested here is that the benefits of molecular manufacturing might not be distributed equitably unless we make certain choices. We still believe this, and although we have offered arguments to support our position and engaged others in discussion, the issue is still open and may not be decided for quite some time. It’s really an old, classic debate about how much the state should intervene in markets, but we think the unprecedented potential productivity of advanced nanotechnology makes it more relevant than ever. We will continue to emphasize this aspect of our message.

Unwise use of nanotechnology can be very dangerous. Over the years, perhaps not surprisingly, this point has brought more attention to CRN than any other. We have raised concerns about the potential for a new arms race, about environmental implications, about job loss and economic disruption, about ubiquitous intrusive surveillance, and many other dangers. We’re gratified that the public at large seems to have caught on to the seriousness of the risks we’ve raised and placed them in proper perspective versus the still important but less critical worries about things like nanoparticle toxicity. Of course, there is nothing close to agreement on CRN’s assertion that “some restrictions, implemented worldwide, will probably be necessary for sufficient control of the use of molecular manufacturing.” That’s one of our most controversial positions, but we have not yet seen a reason to change it.

Nanofactory technology can be used safely. We’re proud to have taken the lead in proposing extensive plans for safe use of personal nanofactories. Our suggested approach of wide distribution combined with built-in technical restrictions almost always garners positive response. Granted, it will be anything but easy to design and implement such a system, but the basic concepts seem to be sound.

Preventing nanotechnology is impossible; careful study will be necessary for wise use. This point was made against a backdrop of some individuals and groups calling for a moratorium on nanotechnology research and development or even outright relinquishment of the technology. Fortunately, such cries have found little sympathy. CRN’s position that advanced nanotechnology should be developed as fast as it can be done safely and responsibly appears to be the mainstream consensus, and with good reason. The potential benefits are far too great to be relinquished, and the best way to head off risks is to carefully study and understand the technology, and then to develop it under sensible guidelines.

Effective use of nanotechnology will require intelligent and prudent policy-making. There are three key points in this position: first, that the issues involved are complex and overlapping, meaning that no simple solution will work; second, that a laissez faire approach could be very dicey because the dangers are too great to allow for unregulated dissemination of nanofactory technology; and, third, that policy choices must be made and administrative systems put in place before the technology is complete. The first point seems self-evident and has largely been accepted, although we suspect that the enormous implications of this overwhelming complexity are not yet fully appreciated. The second point is controversial, of course, and this is an area where CRN is open to considering that we might be wrong. Good arguments can be made for the effectiveness indeed, perhaps even the necessity of supporting emergent networked solutions instead of top-down imposed solutions. That’s an ongoing discussion. The third point is equally controversial, and arguably unachievable, but because it focuses attention on how molecular manufacturing is potentially so disruptive, we think it is worth bringing up again and again.

The situation is urgent; nanofactories may be developed within a decade. Now, we get to the heart of the matter. Unless CRN can establish the urgency factor suggested by this final point, then all of the other positions stated above may be considered only of academic interest and not necessary for critical debate, or at least not for a long time. So, where are we today?

Since CRN was founded in December 2002, we’ve seen remarkable progress in the development of technologies that may contribute to the eventual achievement of exponential general-purpose molecular manufacturing. We won’t go down the whole list, because it is too long (see the Enabling Nanotech Update above for some examples), but it now seems obvious to us and to many scientists and other observers that the feasibility question is well on its way to being settled. The contention that building productive nanoscale machinery is impossible for this reason or that reason has faded into the background. On the point of whether or not molecular manufacturing is feasible, CRN and our allies apparently have won the argument.

A larger question exists, however, about urgency. Feasibility is only one factor; the other is imminence. There is a huge difference between saying that nanofactories will be developed someday and saying that they will be developed soon. We have based our appeals to policy makers and to the public on the idea that immediate action was needed. Originally, we claimed that the technology “might become a reality by 2010, likely will by 2015, and almost certainly will by 2020.” Recently we revised that projection to say “might become a reality by 2010 to 2015, more plausibly will by 2015 to 2020, and almost certainly will by 2020 to 2025.”

It’s interesting to note that while CRN’s time frame for the expected development of molecular manufacturing has shifted back by approximately five years, the mainstream scientific community’s position has been moving forward, from a point of ‘never’, to ‘maybe by the end of the century’, to ‘not until at least 2050’, and now to ‘perhaps around 2030 or so’. These projections might not yet match up exactly with CRN’s, but the gap is steadily shrinking.

So, we’re seeing agreement about feasibility, and a convergence around the likely time frame. These are both positive developments, as uncertainty is being removed.

And that’s where we stand today. The Center for Responsible Nanotechnology has accomplished a great deal in five years, clarifying and sharpening the discussion, forcing our concerns onto the agenda, and moving the mainstream closer to our positions. Our challenge now is to take a step back and see what we most want to achieve during the next five years.


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